Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.51 |
| ▸ | CXCR4 | P61073 | 11/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983240 | 1.00 | HDAC1 (0.51) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL30983280 | 0.89 | HDAC1 (0.52) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL30983293 | 0.86 | HDAC1 (0.51) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL31380388 | 0.85 | HDAC1 (0.50) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL30983310 | 0.85 | HDAC1 (0.48) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL30983220 | 0.85 | HDAC1 (0.50) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL30983279 | 0.84 | HDAC1 (0.49) | HDAC1HDAC6CXCR4HDAC8HDAC5 | |
| SCHEMBL31324080 | 0.84 | HDAC1 (0.55) | HDAC1HDAC6CXCR4HDAC8CYP3A4 | |
| SCHEMBL31380390 | 0.84 | HDAC1 (0.55) | HDAC1HDAC6CXCR4HDAC8CYP3A4 | |
| SCHEMBL31380339 | 0.84 | HDAC1 (0.48) | HDAC1HDAC6CXCR4CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |