Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31380358 | 0.86 | HDAC1 (0.48) | HDAC1HDAC6CXCR4KDM4EKMT2A | |
| SCHEMBL30983240 | 0.84 | HDAC1 (0.51) | HDAC1HDAC6CXCR4CYP2D6CYP3A4 | |
| SCHEMBL31380322 | 0.84 | HDAC1 (0.51) | HDAC1HDAC6CXCR4CYP2D6CYP3A4 | |
| SCHEMBL31380390 | 0.81 | HDAC1 (0.55) | HDAC1HDAC6CXCR4KMT2AADORA2A | |
| SCHEMBL31324080 | 0.81 | HDAC1 (0.55) | HDAC1HDAC6CXCR4KMT2AADORA2A | |
| SCHEMBL30983280 | 0.80 | HDAC1 (0.52) | HDAC1HDAC6CXCR4CYP2D6CYP3A4 | |
| SCHEMBL23774817 | 0.78 | HDAC1 (0.53) | HDAC1HDAC6CXCR4 | |
| SCHEMBL31380393 | 0.78 | HDAC1 (0.53) | HDAC1HDAC6CXCR4TAOK1TAOK3 | |
| SCHEMBL25217720 | 0.78 | HDAC1 (0.53) | HDAC1HDAC6CXCR4 | |
| SCHEMBL31380398 | 0.78 | HDAC1 (0.53) | HDAC1HDAC6CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |