Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 15/20 | 0.38 |
| ▸ | TNKS | O95271 | 3/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31540431 | 1.00 | POLB (0.46) | POLBPRMT5WDR77PARP1TNKS | |
| SCHEMBL31380379 | 0.88 | PRMT5 (0.44) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL31540433 | 0.88 | PRMT5 (0.44) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL31380368 | 0.82 | PRMT5 (0.50) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL31540423 | 0.82 | PRMT5 (0.50) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL31540443 | 0.76 | PRMT5 (0.57) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL31380359 | 0.72 | PRMT5 (0.61) | PRMT5WDR77PARP1TNKSTNKS2 | |
| SCHEMBL23087732 | 0.67 | POLB (0.66) | POLBPRMT5WDR77PARP1 | |
| SCHEMBL31380334 | 0.65 | PRMT5 (0.53) | PRMT5WDR77PARP1 | |
| SCHEMBL14161293 | 0.64 | HSD11B1 (0.50) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |