SCHEMBL3138244

SCHEMBL3138244

NC1=NC(=O)[N]C=C1Br

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14793581 0.66
SCHEMBL7603416 0.64
SCHEMBL14793665 0.63
SCHEMBL5604658 0.55
SCHEMBL6315578 0.55
SCHEMBL3148463 0.54
SCHEMBL11004832 0.52
SCHEMBL7267062 0.52
SCHEMBL16497484 0.52
SCHEMBL10910607 0.52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3284832-B1 APTAMER WITH IMPROVED RATE OF DISSOCIATION, AND NON-COVALENT APTAMER-TARGET COMPLEX THEREOF SOMALOGIC OPERATING CO INC (US) 2023-06-07 EP claimed
US-11597745-B2 β-modified phosphoric acid compound precursor, β-modified phosphoric acid compound, reaction inhibitor and medicine containing the same, and method for inhibiting reaction JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2023-03-07 US claimed
EP-3284832-A2 METHOD FOR GENERATING APTAMERS WITH IMPROVED OFF-RATES Somalogic, Inc. (US) 2018-02-21 EP claimed
EP-2933340-B1 Aptamers with uridines and/or thymidines substituted at the 5-position with a benzyl group SOMALOGIC INC (US) 2017-09-06 EP claimed
US-20170137819-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. 2017-05-18 US claimed
EP-2933340-A1 Chemically modified aptamers with improved off-rates Somalogic, Inc. (US) 2015-10-21 EP claimed
US-20150197753-A1 Method for Generating Aptamers with Improved Off-Rates SOMALOGIC, INC. 2015-07-16 US claimed
US-8975388-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2015-03-10 US claimed
US-8404830-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2013-03-26 US claimed
US-8076310-B2 Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production K.U.LEUVEN RESEARCH & DEVELOPMENT (BE) 2011-12-13 US claimed
US-7687500-B2 Substituted oxetanes, method of making, and method of use thereof THE UNIVERSITY OF CONNECTICUT (US) 2010-03-30 US claimed
US-20080139566-A1 SUBSTITUTED OXETANES, METHOD OF MAKING, AND METHOD OF USE THEREOF HOWELL AMY R 2008-06-12 US claimed
JP-2007512358-A 2007-05-17 JP claimed
EP-1685127-A1 HETEROCYCLYL-SUBSTITUTED OXETANES FOR THE TREATMENT OF PROLIFERATIVE OR INFECTIOUS DISEASES The University of Connecticut (US) 2006-08-02 EP claimed
US-20050215568-A1 Substituted oxetanes, method of making, and method of use thereof UNIVERSITY OF CONNECTICUT, THE 2005-09-29 US claimed
WO-2005051944-A1 HETEROCYCLYL-SUBSTITUTED OXETANES FOR THE TREATMENT OF PROLIFERATIVE OR INFECTIOUS DISEASES UNIVERSITY OF CONNECTICUT (US) 2005-06-09 WO claimed
WO-2000059906-A1 AMINOHETEROCYCLE-SUBSTITUTED GLYCEROLS CLARION PHARMACEUTICALS, INC. (US) 2000-10-12 WO claimed
US-6015886-A ANTISENSE AGENTS WITH MODIFICATIONS INCLUDING P-ALKOXY AND 2'-O-METHYL GROUPS; NUCLEASE RESISTANT, ABILITY TO ACTIVATE BACTERIAL RIBONUCLEASE H, FORM STABLE DUPLEXES WITH RNA, AND HAVE STRONG HYDROPHOBICITY FOR EFFICIENT CELLULAR UPTAKE CHEMGENES CORPORATION (US) 2000-01-18 US claimed
US-5891881-A PROPANE 1,2,3-SUBSTITUTED WITH ONE OF EACH: ETHER OR SULFIDE GROUP; HYDROXY GROUP; AND AMINOHETEROCYCLIC GROUP; WOUND HEALING PROMOTER FOR MAMMALS CLARION PHARMACEUTICALS INC. (US) 1999-04-06 US claimed
US-11597745-B2 β-modified phosphoric acid compound precursor, β-modified phosphoric acid compound, reaction inhibitor and medicine containing the same, and method for inhibiting reaction JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2023-03-07 US disclosed
US-10253153-B2 Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support NITTO DENKO CORPORATION (JP) 2019-04-09 US disclosed
US-20160311847-A1 LINKER AND SUPPORT FOR SOLID PHASE SYNTHESIS OF NUCLEIC ACID, AND PRODUCTION METHOD OF NUCLEIC ACID USING SAID SUPPORT NITTO DENKO CORPORATION (JP) 2016-10-27 US disclosed
US-8404830-B2 Method for generating aptamers with improved off-rates SOMALOGIC, INC. (US) 2013-03-26 US disclosed
US-7687500-B2 Substituted oxetanes, method of making, and method of use thereof THE UNIVERSITY OF CONNECTICUT (US) 2010-03-30 US disclosed
US-20080139566-A1 SUBSTITUTED OXETANES, METHOD OF MAKING, AND METHOD OF USE THEREOF HOWELL AMY R 2008-06-12 US disclosed
US-7351827-B2 Substituted oxetanes, method of making, and method of use thereof THE UNIVERSITY OF CONNECTICUT (US) 2008-04-01 US disclosed
EP-1685127-A1 HETEROCYCLYL-SUBSTITUTED OXETANES FOR THE TREATMENT OF PROLIFERATIVE OR INFECTIOUS DISEASES The University of Connecticut (US) 2006-08-02 EP disclosed
US-20050215568-A1 Substituted oxetanes, method of making, and method of use thereof UNIVERSITY OF CONNECTICUT, THE 2005-09-29 US disclosed
WO-2005051944-A1 HETEROCYCLYL-SUBSTITUTED OXETANES FOR THE TREATMENT OF PROLIFERATIVE OR INFECTIOUS DISEASES UNIVERSITY OF CONNECTICUT (US) 2005-06-09 WO disclosed
US-6015886-A ANTISENSE AGENTS WITH MODIFICATIONS INCLUDING P-ALKOXY AND 2'-O-METHYL GROUPS; NUCLEASE RESISTANT, ABILITY TO ACTIVATE BACTERIAL RIBONUCLEASE H, FORM STABLE DUPLEXES WITH RNA, AND HAVE STRONG HYDROPHOBICITY FOR EFFICIENT CELLULAR UPTAKE CHEMGENES CORPORATION (US) 2000-01-18 US disclosed
US-6015886-A ANTISENSE AGENTS WITH MODIFICATIONS INCLUDING P-ALKOXY AND 2'-O-METHYL GROUPS; NUCLEASE RESISTANT, ABILITY TO ACTIVATE BACTERIAL RIBONUCLEASE H, FORM STABLE DUPLEXES WITH RNA, AND HAVE STRONG HYDROPHOBICITY FOR EFFICIENT CELLULAR UPTAKE CHEMGENES CORPORATION (US) 2000-01-18 US disclosed