Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tenofovir Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 15/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.70 |
| ▸ | FAP | Q12884 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tenofovir Anhydrous SCHEMBL39724 | 0.99 | CYP3A4 (1.00) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL29355255 | 0.99 | CYP3A4 (1.00) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL18894359 | 0.99 | CYP3A4 (1.00) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL2040329 | 0.99 | CYP3A4 (1.00) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL497725 | 0.99 | CYP3A4 (1.00) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL3133902 | 0.98 | CYP3A4 (0.98) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL20295138 | 0.98 | CYP3A4 (0.98) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL400718 | 0.98 | CYP3A4 (0.98) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL901180 | 0.98 | CYP3A4 (0.98) | CYP3A4CYP2D6FAP | |
| Tenofovir Anhydrous SCHEMBL3967109 | 0.98 | CYP3A4 (0.98) | CYP3A4CYP2D6FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026603-A2 | NOVEL AMINE SALTS OF TENOFOVIR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF IN PRODUCTION OF TENOFOVIR DIOPROXIL | MATRIX LABORATORIES LIMITED (IN) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026603-A2 | NOVEL AMINE SALTS OF TENOFOVIR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF IN PRODUCTION OF TENOFOVIR DIOPROXIL | MATRIX LABORATORIES LIMITED (IN) | 2010-03-11 | — | — | WO | disclosed |