Tenofovir Anhydrous

Tenofovir Anhydrous

SCHEMBL39724

C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

Ppol

The experimentally established mechanism targets of Tenofovir Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 14/20 1.00
CYP2D6 P10635 14/20 0.70
FAP Q12884 1/20 0.66
FGFR1 P11362 1/20 0.62
SLC22A6 Q4U2R8 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tenofovir Anhydrous SCHEMBL18894359 1.00 CYP3A4 (1.00) CYP3A4CYP2D6FAPFGFR1SLC22A6
Tenofovir Anhydrous SCHEMBL29355255 1.00 CYP3A4 (1.00) CYP3A4CYP2D6FAPFGFR1SLC22A6
Tenofovir Anhydrous SCHEMBL2040329 1.00 CYP3A4 (1.00) CYP3A4CYP2D6FAPFGFR1SLC22A6
Tenofovir Anhydrous SCHEMBL497725 1.00 CYP3A4 (1.00) CYP3A4CYP2D6FAPFGFR1SLC22A6
Tenofovir Anhydrous SCHEMBL18492311 0.99 CYP3A4 (0.98) CYP3A4CYP2D6FAP
Tenofovir Anhydrous SCHEMBL20295138 0.99 CYP3A4 (0.98) CYP3A4CYP2D6FAP
Tenofovir Anhydrous SCHEMBL19586794 0.99 CYP3A4 (0.98) CYP3A4CYP2D6FAP
Tenofovir Anhydrous SCHEMBL3133933 0.99 CYP3A4 (0.98) CYP3A4CYP2D6FAP
Tenofovir Anhydrous SCHEMBL400718 0.99 CYP3A4 (0.98) CYP3A4CYP2D6FAP
Tenofovir Anhydrous SCHEMBL22206868 0.99 CYP3A4 (0.98) CYP3A4CYP2D6FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 36069 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4746907-A1 METHOD OF TREATMENT OF HIV INFECTION WITH VACCINE Gilead Sciences, Inc. (US) 2026-05-27 EP claimed
WO-2026107341-A1 COMBINATION THERAPY FOR TREATING HEPATITIS B VIRUS (HBV) INFECTION Vir Biotechnology, Inc. (US) 2026-05-21 WO claimed
US-20260139860-A1 PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS CENTRE FOR DIGESTIVE DISEASES (AU) 2026-05-21 US claimed
EP-4094767-B1 NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO UNIV EMORY (US) 2026-05-20 EP claimed
CN-122070288-A Bridged tricyclic carbamoyl pyridone compounds and uses thereof 吉利德科学公司 2026-05-19 CN claimed
CN-122055369-A Bridged tricyclic carbamoyl pyridone compounds and uses thereof 吉利德科学公司 2026-05-15 CN claimed
CN-122036801-A Crystalline forms of tenofovir alafenamide 吉利德科学公司 2026-05-15 CN claimed
CN-122055373-A Bridged tricyclic carbamoyl pyridone compounds and uses thereof 吉利德科学公司 2026-05-15 CN claimed
EP-3829559-B1 INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION MERCK SHARP & DOHME LLC (US) 2026-05-13 EP claimed
US-20260124290-A1 HIV Immunogens, Vaccines, and Methods Related Thereto UNIV EMORY (US) 2026-05-07 US claimed
WO-2002033402-A2 ESTABLISHMENT OF BIOLOGICAL CUT-OFF VALUES FOR PREDICTING RESISTANCE TO THERAPY VIRCO BVBA (BE) 2002-04-25 WO claimed
WO-2002000613-A2 INHIBITORS OF HEPATITIS B VIRUS INFECTION AXXIMA PHARMACEUTICALS AG (DE) 2002-01-03 WO claimed
WO-2001097749-A2 THE USE OF SYNTHETIC, NON-HORMONAL 21-AMINOSTEROIDS AND THEREOF KOTZE, GAVIN, SALOMON (ZA) 2001-12-27 WO claimed
WO-2001047511-A2 TREATMENT OF DRUG-RESISTANT HUMAN IMMUNODEFICIENCY VIRUS INFECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-07-05 WO claimed
WO-2001039724-A2 PHOSPHONATE COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) 2001-06-07 WO claimed
US-6194391-B1 CS-87 (TITLE COMPOUND) INDUCES A TRANSIENT MUTATION IN HIV-1 AT THE 70TH CODON OF THE REVERSE TRANSCRIPTASE REGION OF THE VIRUS; ADMINISTERING TO A HUMAN IN NEED OF THERAPY WITH A DRUG THAT INDUCES A MUTATION IN HIV-1 AT ANOTHER LOCATION EMORY UNIVERSITY 2001-02-27 US claimed
US-6057305-A Antiretroviral enantiomeric nucleotide analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 2000-05-02 US claimed
EP-0654037-B1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS ACAD OF SCIENCE CZECH REPUBLIC (CZ) 1999-05-12 EP claimed
EP-0654037-A1 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1995-05-24 EP claimed
WO-1994003467-A2 ANTIRETROVIRAL ENANTIOMERIC NUCLEOTIDE ANALOGS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1994-02-17 WO claimed