Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1643973 | 1.00 | RXFP1 (0.56) | RXFP1KDM4EHSD17B10CA1CA2 | |
| SCHEMBL26921670 | 0.92 | RXFP1 (0.49) | RXFP1KDM4EHSD17B10CA1CA2 | |
| SCHEMBL26921845 | 0.91 | RXFP1 (0.48) | RXFP1KDM4EHSD17B10CA1CA2 | |
| SCHEMBL7001806 | 0.84 | RXFP1 (0.56) | RXFP1KDM4EHSD17B10CA1CA2 | |
| SCHEMBL30521190 | 0.84 | RXFP1 (0.56) | RXFP1KDM4EHSD17B10CA1CA2 | |
| SCHEMBL12596677 | 0.84 | RXFP1 (0.56) | RXFP1KDM4EHSD17B10CA1CA2 | |
| SCHEMBL27187155 | 0.83 | EPHX1 (0.38) | RXFP1EPHX1ALDH1A1MAPTNPC1 | |
| SCHEMBL31387781 | 0.82 | TSHR (0.44) | RXFP1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL21631612 | 0.82 | TSHR (0.44) | RXFP1KDM4EALDH1A1MAPTPOLB | |
| SCHEMBL26921145 | 0.81 | LDHA (0.41) | RXFP1KDM4EHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513050-B | Heterocyclic compounds which inhibit SHP2 activity | 大鹏药品工业株式会社 | 2024-12-20 | — | — | CN | disclosed |