Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 11/20 | 0.76 |
| ▸ | PRKCI | P41743 | 4/20 | 0.66 |
| ▸ | GRM5 | P41594 | 1/20 | 0.63 |
| ▸ | PRKDC | P78527 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059993 | 1.00 | ATR (0.76) | ATRPRKCIGRM5PRKDCCYP3A4 | |
| SCHEMBL559881 | 0.87 | ATR (1.00) | ATRGRM5PRKDCCYP3A4 | |
| SCHEMBL15724439 | 0.86 | ATR (0.68) | ATRPRKCIGRM5PRKDCCYP3A4 | |
| SCHEMBL411951 | 0.85 | ATR (0.75) | ATRPRKCIGRM5PRKDCCYP3A4 | |
| SCHEMBL1586135 | 0.84 | ATR (0.74) | ATRPRKCIGRM5PRKDCCYP3A4 | |
| SCHEMBL14136995 | 0.82 | ATR (0.52) | ATRPRKCIGRM5PRKDCCYP3A4 | |
| SCHEMBL1800565 | 0.81 | ATR (0.58) | ATRPRKCIGRM5PRKDCCYP3A4 | |
| SCHEMBL25346973 | 0.81 | PRKCI (0.55) | ATRPRKCIPRKDC | |
| SCHEMBL19101125 | 0.80 | ATR (0.90) | ATRPRKDCCYP3A4 | |
| SCHEMBL31388033 | 0.79 | ATR (0.68) | ATRPRKCIGRM5PRKDCCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341127-B | Aminopyrazine compounds as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-12-17 | — | — | CN | disclosed |