Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | WIZ | O95785 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3085402 | 0.79 | SCN1A (0.52) | HTR2AHTR2CHTR2BSCN1ASCN5A | |
| SCHEMBL13154008 | 0.74 | HTR2C (0.59) | HTR2AHTR2CHTR2BSCN1ASCN5A | |
| SCHEMBL31409498 | 0.70 | HTR2A (0.53) | HTR2AHTR2CHTR2BSCN1ASCN5A | |
| SCHEMBL31312250 | 0.68 | HTR2A (0.53) | HTR2AHTR2CHTR2BSCN1ASCN5A | |
| SCHEMBL22835504 | 0.67 | MAOA (0.53) | HTR2AHTR2CHTR2BSCN1ASCN5A | |
| Trifluoroacetic Acid SCHEMBL3089861 | 0.66 | HTR2A (0.50) | HTR2AHTR2CHTR2BSCN1ASCN5A | |
| SCHEMBL3089987 | 0.66 | SCN1A (0.55) | SCN1ASCN5ASCN9A | |
| SCHEMBL12043662 | 0.64 | KCNH2 (0.49) | HTR2AHTR2CHTR2BADAM17 | |
| SCHEMBL19503638 | 0.64 | CRBN (0.65) | CSNK1A1CRBNIKZF2 | |
| SCHEMBL20766684 | 0.63 | HTR2A (0.51) | HTR2AHTR2CHTR2BWIZCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | claimed |