Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.41 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31388966 | 0.91 | AAK1 (0.39) | AAK1PSMB1PSMB5 | |
| SCHEMBL25318426 | 0.82 | AAK1 (0.40) | AAK1PSMB1PSMB5 | |
| SCHEMBL31058394 | 0.82 | AAK1 (0.40) | AAK1PSMB1PSMB5 | |
| SCHEMBL25318429 | 0.82 | AAK1 (0.40) | AAK1PSMB1PSMB5 | |
| SCHEMBL25320533 | 0.81 | TIPARP (0.40) | AAK1TIPARPPSMB1PSMB5 | |
| SCHEMBL25320536 | 0.81 | TIPARP (0.40) | AAK1TIPARPPSMB1PSMB5 | |
| SCHEMBL31362889 | 0.79 | AAK1 (0.37) | AAK1PSMB1PSMB5 | |
| SCHEMBL25322149 | 0.77 | AAK1 (0.38) | AAK1TIPARPPSMB1PSMB5 | |
| SCHEMBL25322154 | 0.77 | AAK1 (0.38) | AAK1TIPARPPSMB1PSMB5 | |
| SCHEMBL25319637 | 0.76 | PSMB1 (0.40) | AAK1PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066328-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. | 2025-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066328-A1 | PARP7 INHIBITORS | PARP1, PARP2, PARP8 | AAK1 2461/4885TIPARP 524/4885PSMB1 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.