Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PHGDH | O43175 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31389771 | 0.94 | SIGMAR1 (0.38) | SIGMAR1KCNH2WDR5ACHEHDAC1 | |
| SCHEMBL19945657 | 0.90 | HDAC1 (0.36) | SIGMAR1KCNH2HDAC1HDAC6KDM4E | |
| SCHEMBL20244826 | 0.84 | SIGMAR1 (0.42) | SIGMAR1KCNH2WDR5HDAC1HDAC6 | |
| SCHEMBL24915358 | 0.82 | SIGMAR1 (0.41) | SIGMAR1HDAC1HDAC6JAK2JAK1 | |
| SCHEMBL24958728 | 0.82 | MEN1 (0.37) | ALDH1A1MEN1KMT2A | |
| SCHEMBL14553997 | 0.81 | SIGMAR1 (0.40) | SIGMAR1KCNH2WDR5ACHEHDAC1 | |
| SCHEMBL17493993 | 0.81 | KCNH2 (0.40) | SIGMAR1KCNH2WDR5ACHEHDAC1 | |
| SCHEMBL29160328 | 0.80 | SIGMAR1 (0.38) | SIGMAR1JAK2JAK1MGLL | |
| SCHEMBL29341832 | 0.80 | TLR8 (0.37) | SIGMAR1JAK2JAK1 | |
| SCHEMBL18290465 | 0.79 | SIGMAR1 (0.38) | SIGMAR1KCNH2WDR5HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043225-A2 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 2 | GENENTECH, INC. (US) | 2025-02-27 | — | — | WO | disclosed |