SCHEMBL31393136

SCHEMBL31393136

Cc1c(N)cc(Br)cc1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.38
AR P10275 1/20 0.37
KDM1A O60341 2/20 0.36
TSHR P16473 2/20 0.33
FFAR4 Q5NUL3 2/20 0.33
FFAR1 O14842 1/20 0.33
GLA P06280 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
NOTUM Q6P988 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
CA6 P23280 1/20 0.32
CA5A P35218 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
CA5B Q9Y2D0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31436477 1.00 CFTR (0.38) CFTRARKDM1ATSHRFFAR4
SCHEMBL720822 0.78 KDM1A (0.38) CFTRARKDM1ATSHRFFAR4
SCHEMBL24118132 0.78 TSHR (0.45) CFTRARTSHRFFAR4GLA
SCHEMBL15761590 0.78 SMN1; SMN2 (0.41) CFTRARTSHRFFAR4GLA
SCHEMBL13550103 0.78 AR (0.35) ARKDM1ANOTUMSMN1; SMN2
SCHEMBL3282157 0.77 PTPN5 (0.41) CFTRARTSHRGLAPOLB
SCHEMBL3678341 0.77 CYP3A4 (0.43) TSHRPOLBGAAHSD17B10SMN1; SMN2
SCHEMBL30506009 0.75 AR (0.37) CFTRARKDM1ATSHRGLA
SCHEMBL25111549 0.75 KDM1A (0.33) CFTRARKDM1ANOTUM
SCHEMBL2436616 0.75 AR (0.37) CFTRARKDM1ATSHRGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122055363-A Compounds and methods for modulating splicing 雷密克斯医疗公司 2026-05-15 CN disclosed
EP-4724438-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2026-04-15 EP disclosed
WO-2024259015-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2024-12-19 WO disclosed