SCHEMBL3678341

SCHEMBL3678341

Cc1c(N)cc(Br)cc1N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.43
TSHR P16473 4/20 0.43
MAPK1 P28482 2/20 0.43
PIK3CA P42336 1/20 0.43
ALDH1A1 P00352 6/20 0.40
ALOX15 P16050 2/20 0.40
CYP1A2 P05177 1/20 0.40
CASP7 P55210 1/20 0.40
HIF1A Q16665 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 4/20 0.38
CD44 P16070 1/20 0.38
IDO1 P14902 1/20 0.37
TDO2 P48775 1/20 0.37
MAPT P10636 2/20 0.35
NPC1 O15118 1/20 0.35
HTT P42858 1/20 0.35
UHRF1 Q96T88 1/20 0.35
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16728590 0.89 ALDH1A1 (0.44) CYP3A4TSHRMAPK1PIK3CAALDH1A1
SCHEMBL6670544 0.86 CYP3A4 (0.43) CYP3A4TSHRMAPK1PIK3CAALDH1A1
SCHEMBL29548253 0.86 CYP3A4 (0.43) CYP3A4TSHRMAPK1PIK3CAALDH1A1
SCHEMBL28012835 0.86 CYP3A4 (0.38) CYP3A4TSHRMAPK1PIK3CAALDH1A1
SCHEMBL3670333 0.82 ALDH1A1 (0.48) CYP3A4TSHRMAPK1ALDH1A1ALOX15
SCHEMBL560909 0.82 CYP3A4 (0.35) CYP3A4TSHRMAPK1ALDH1A1ALOX15
SCHEMBL2921387 0.78 POLB (0.48) CYP3A4TSHRALDH1A1ALOX15HSD17B10
SCHEMBL20170317 0.77 ERN1 (0.44) CYP3A4TSHRMAPK1ALDH1A1ALOX15
SCHEMBL31393136 0.77 CFTR (0.38) CYP3A4TSHRMAPK1ALDH1A1ALOX15
SCHEMBL31436477 0.77 CFTR (0.38) CYP3A4TSHRMAPK1ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1426392-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2010-02-24 EP disclosed
US-6960640-B2 Composition for optical material MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 2005-11-01 US disclosed
US-20040147708-A1 Composition for optical material MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-07-29 US disclosed
EP-1426392-A1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-06-09 EP disclosed