Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30816242 | 0.83 | ADRA2A (0.47) | ADRA2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL27204277 | 0.83 | ADRA2A (0.47) | ADRA2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL27159912 | 0.83 | ADRA2A (0.47) | ADRA2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL12269707 | 0.80 | GAA (0.41) | HTTALDH1A1RAB9AKDM4E | |
| SCHEMBL19658610 | 0.77 | ADRA2A (0.42) | ADRA2AKDM4C | |
| SCHEMBL27817330 | 0.74 | ADRA2A (0.47) | ADRA2AMAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL1843412 | 0.73 | ADRA2A (0.46) | ADRA2AMAPTHTTHCRTR2LMNA | |
| SCHEMBL25202695 | 0.71 | ADRA2A (0.50) | ADRA2AMAPTHTTHCRTR2LMNA | |
| SCHEMBL1271967 | 0.71 | MAP3K14 (0.51) | ADRA2AMAPTHTTHCRTR2LMNA | |
| SCHEMBL28768358 | 0.71 | ADRA2A (0.42) | ADRA2AMAPTHTTALDH1A1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739307-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | The General Hospital Corporation (US) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025010291-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-09 | — | — | WO | disclosed |