Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.52 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.48 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29072485 | 1.00 | ABHD6 (0.56) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL29072494 | 1.00 | ABHD6 (0.56) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL29072487 | 1.00 | ABHD6 (0.56) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL31395561 | 0.85 | ABHD6 (0.56) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL2185429 | 0.82 | NOTUM (0.63) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL25591463 | 0.82 | DPP8 (0.51) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL25591461 | 0.81 | ABHD6 (0.50) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL17278349 | 0.80 | ACE (0.68) | DPP8DPP7ACEHDAC8RAB9A | |
| SCHEMBL587507 | 0.80 | ABHD6 (0.59) | ABHD6DPP8DPP9DPP7CARM1 | |
| SCHEMBL30575080 | 0.80 | ABHD6 (0.60) | ABHD6DPP8DPP9DPP7CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739307-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | The General Hospital Corporation (US) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025010291-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-09 | — | — | WO | disclosed |