Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279335 | 0.83 | DHODH (0.56) | DHODHGRM4MAPTRAB9AMAPK1 | |
| SCHEMBL30114249 | 0.81 | EPHX2 (0.56) | DHODHRAB9ACYP1A2CYP3A4TDP1 | |
| SCHEMBL24879902 | 0.81 | EPHX2 (0.56) | DHODHRAB9ACYP1A2CYP3A4TDP1 | |
| SCHEMBL25339954 | 0.81 | PIP4K2A (0.44) | DHODHGRM4MAPTNPC1RAB9A | |
| SCHEMBL30519327 | 0.81 | PIP4K2A (0.44) | DHODHGRM4MAPTNPC1RAB9A | |
| SCHEMBL11398989 | 0.79 | CA12 (0.62) | DHODHGRM4MAPTKDRNPC1 | |
| SCHEMBL14818781 | 0.79 | RAB9A (0.63) | DHODHGRM4MAPTKDRNPC1 | |
| SCHEMBL2041513 | 0.78 | DHODH (0.56) | DHODHGRM4MAPTKDRNPC1 | |
| SCHEMBL23319512 | 0.78 | ABCG2 (0.50) | DHODHKDRNPC1RAB9AKDM4E | |
| SCHEMBL20406647 | 0.78 | TRPV1 (0.48) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739307-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | The General Hospital Corporation (US) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025010291-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-09 | — | — | WO | disclosed |