Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25391509 | 0.86 | ALDH1A1 (0.53) | TTRHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16742124 | 0.83 | TTR (0.44) | TTRHPGDNPSR1MEN1KMT2A | |
| SCHEMBL16742122 | 0.83 | TTR (0.44) | TTRHPGDNPSR1MEN1KMT2A | |
| SCHEMBL17113270 | 0.80 | MEN1 (0.52) | HPGDNPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3350012 | 0.79 | PLK1 (0.44) | HPGDMEN1KMT2ASMN1; SMN2PLK1 | |
| SCHEMBL3959311 | 0.79 | TTR (0.47) | TTRMEN1KMT2APLK1ALDH1A1 | |
| SCHEMBL3072318 | 0.79 | ALDH1A1 (0.44) | NPSR1PLK1ALDH1A1MAPK1STAT3 | |
| SCHEMBL16742098 | 0.77 | TTR (0.46) | TTRNPSR1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL24819228 | 0.77 | TTR (0.46) | TTRNPSR1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL16742183 | 0.77 | TSHR (0.41) | HPGDSMN1; SMN2PLK1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739307-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | The General Hospital Corporation (US) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025010291-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-09 | — | — | WO | disclosed |