Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 7/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | ABL2 | P42684 | 2/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398986 | 0.87 | MAP4K4 (0.44) | MAP4K4SRCEGFRPIK3CDABL1 | |
| SCHEMBL31398880 | 0.87 | POLB (0.42) | MAP4K4SRCEGFRPIK3CDNR1H2 | |
| SCHEMBL31398992 | 0.77 | FGFR2 (0.46) | SRCEGFRABL1ABL2KDR | |
| SCHEMBL31398952 | 0.76 | POLB (0.42) | MAP4K4SRCEGFRPIK3CDNR1H2 | |
| SCHEMBL22347133 | 0.76 | MAP4K4 (0.53) | MAP4K4SRCEGFRPIK3CDABL1 | |
| SCHEMBL22359270 | 0.76 | MAP4K4 (0.46) | MAP4K4SRCEGFRPIK3CDABL1 | |
| SCHEMBL31308148 | 0.76 | MAP4K4 (0.53) | MAP4K4SRCEGFRPIK3CDABL1 | |
| SCHEMBL31398872 | 0.73 | SRC (0.54) | SRCEGFRPIK3CDABL1ABL2 | |
| SCHEMBL31398881 | 0.73 | SRC (0.54) | SRCEGFRPIK3CDABL1ABL2 | |
| SCHEMBL25283747 | 0.70 | FLT3 (0.47) | MAP4K4SRCEGFRPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119176813-A | Tricyclic heterocyclic compound with FGFR inhibition effect, pharmaceutical composition containing tricyclic heterocyclic compound and application of pharmaceutical composition | 上海科恩泰生物医药科技有限公司 | 2024-12-24 | — | — | CN | disclosed |