Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | CYBB | P04839 | 1/20 | 0.36 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.36 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398986 | 0.87 | MAP4K4 (0.44) | NR1H2MKNK1PIK3CDMAP4K4EGFR | |
| SCHEMBL31398880 | 0.87 | POLB (0.42) | POLBNR1H2MKNK1MAPK8CNR1 | |
| SCHEMBL31398918 | 0.81 | UCHL1 (0.35) | MEN1KMT2APIK3CDTSHR | |
| SCHEMBL31398962 | 0.80 | UCHL1 (0.33) | PIK3CDTSHREGFRSRC | |
| SCHEMBL31398985 | 0.79 | SRC (0.43) | PIK3CDEGFRSRC | |
| SCHEMBL31398994 | 0.79 | MAPK8 (0.32) | MAPK8CNR1CNR2MAP4K4 | |
| SCHEMBL31398949 | 0.76 | MAP4K4 (0.44) | NR1H2PIK3CDMAP4K4EGFRSRC | |
| SCHEMBL31398881 | 0.73 | SRC (0.54) | PIK3CDEGFRSRC | |
| SCHEMBL31398872 | 0.73 | SRC (0.54) | PIK3CDEGFRSRC | |
| SCHEMBL31432 | 0.71 | CSNK1E (0.44) | NR1H2MEN1KMT2AESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119176813-A | Tricyclic heterocyclic compound with FGFR inhibition effect, pharmaceutical composition containing tricyclic heterocyclic compound and application of pharmaceutical composition | 上海科恩泰生物医药科技有限公司 | 2024-12-24 | — | — | CN | disclosed |