Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29857496 | 0.77 | PDE5A (0.58) | ENPP1 | |
| SCHEMBL22299729 | 0.77 | PDE5A (0.58) | ENPP1 | |
| SCHEMBL22290818 | 0.74 | KDM4E (0.45) | HPGDSKDM4ESMN1; SMN2 | |
| SCHEMBL13313218 | 0.72 | JAK2 (0.59) | JAK2JAK1TYK2JAK3HPGDS | |
| SCHEMBL13313235 | 0.71 | JAK2 (0.53) | JAK2JAK1TYK2JAK3HPGDS | |
| SCHEMBL13348747 | 0.71 | JAK2 (0.53) | JAK2JAK1TYK2JAK3HPGDS | |
| SCHEMBL22300106 | 0.69 | MEN1 (0.42) | KDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1634895 | 0.69 | CA1 (0.51) | KDM4ENPC1MAPTRAB9A | |
| SCHEMBL13313229 | 0.69 | JAK2 (0.53) | JAK2JAK1TYK2JAK3HPGDS | |
| SCHEMBL13348749 | 0.69 | JAK2 (0.53) | JAK2JAK1TYK2JAK3HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059218-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2025-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059218-A1 | ENPP1 Inhibitors and Methods of Modulating Immune Response | ENPP1, STING1, ENPP2 | JAK2 3515/4885JAK1 1776/4885TYK2 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.