Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5880446 | 0.78 | HTR2C (0.46) | LRRK2CYP1A2CYP2C9ALDH1A1KDM4E | |
| SCHEMBL20572118 | 0.78 | LRRK2 (0.45) | HTTLRRK2CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL31400781 | 0.75 | NOS3 (0.42) | NOS3NOS1NOS2HTTCYP1A2 | |
| SCHEMBL25124865 | 0.74 | LRRK2 (0.47) | HTTLRRK2CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL10919711 | 0.71 | HTT (0.42) | HTTLRRK2PRKDCALDH1A1KDM4E | |
| SCHEMBL12179269 | 0.70 | LRRK2 (0.52) | LRRK2CYP1A2CYP2C9ALDH1A1KDM4E | |
| SCHEMBL21921211 | 0.70 | LRRK2 (0.52) | LRRK2CYP1A2CYP2C9ALDH1A1KDM4E | |
| SCHEMBL23639194 | 0.70 | PIK3CA (0.46) | HTTLRRK2CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL17583342 | 0.69 | KDM4E (0.57) | LRRK2CYP1A2CYP2C9ALDH1A1KDM4E | |
| SCHEMBL3436634 | 0.69 | CYP1A2 (0.56) | LRRK2CYP1A2CYP2C9ALDH1A1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |