Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12011570 | 1.00 | L3MBTL1 (0.50) | L3MBTL1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL15373443 | 0.83 | GAA (0.43) | L3MBTL1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL18481112 | 0.81 | L3MBTL1 (0.52) | L3MBTL1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL1559057 | 0.80 | HTT (0.46) | NPC1RAB9ASMN1; SMN2HTTGAA | |
| SCHEMBL18479926 | 0.79 | AR (0.44) | NPC1RAB9ASMN1; SMN2HTTGAA | |
| SCHEMBL18483328 | 0.79 | SLC22A12 (0.37) | NPC1RAB9ASMN1; SMN2HTTGAA | |
| SCHEMBL15577665 | 0.79 | L3MBTL1 (0.50) | L3MBTL1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL12266463 | 0.79 | L3MBTL1 (0.50) | L3MBTL1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL12011608 | 0.79 | HDAC4 (0.48) | L3MBTL1NPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL1502539 | 0.79 | NAMPT (0.48) | NPC1RAB9AHTTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |