⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3626862 | 1.00 | — | — | |
| SCHEMBL11956561 | 0.80 | KDM4E (0.38) | — | |
| SCHEMBL21963307 | 0.70 | TSHR (0.35) | — | |
| SCHEMBL4546534 | 0.68 | — | — | |
| SCHEMBL31168638 | 0.67 | ALDH1A1 (0.30) | — | |
| SCHEMBL1861724 | 0.67 | ALDH1A1 (0.30) | — | |
| SCHEMBL943724 | 0.65 | — | — | |
| SCHEMBL8248277 | 0.61 | TSHR (0.37) | — | |
| SCHEMBL11956563 | 0.59 | TSHR (0.39) | — | |
| Hydrochloric Acid SCHEMBL5953218 | 0.59 | ALDH1A1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |