Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | SDHB | P21912 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30263067 | 0.89 | NOTUM (0.40) | GPBAR1NOTUMSDHBPTGS2CA1 | |
| SCHEMBL30263072 | 0.89 | NOTUM (0.43) | GPBAR1NOTUMMRGPRX4SDHBPTGS2 | |
| SCHEMBL29283393 | 0.89 | NOTUM (0.43) | GPBAR1NOTUMMRGPRX4SDHBPTGS2 | |
| SCHEMBL29283387 | 0.89 | NOTUM (0.40) | GPBAR1NOTUMSDHBPTGS2CA1 | |
| SCHEMBL22926045 | 0.86 | AURKA (0.44) | GPBAR1MRGPRX4KAT6APTGS2LMNA | |
| SCHEMBL30714944 | 0.85 | GPBAR1 (0.43) | GPBAR1KAT6APTGS2ALPLCA1 | |
| SCHEMBL23213189 | 0.84 | NOTUM (0.41) | GPBAR1NOTUMMRGPRX4KAT6AALPL | |
| SCHEMBL5619177 | 0.84 | CA1 (0.47) | PTGS2CA1CA2CA7CA9 | |
| SCHEMBL475839 | 0.84 | NOTUM (0.50) | NOTUMMRGPRX4CA1CA2CA7 | |
| SCHEMBL29283385 | 0.82 | NOTUM (0.40) | GPBAR1NOTUMSDHBPTGS2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |