Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26143885 | 0.85 | KDM4A (0.42) | KDM4ADYRK1AGSK3BL3MBTL1 | |
| SCHEMBL30097062 | 0.85 | KDM4A (0.42) | KDM4ADYRK1AGSK3BL3MBTL1 | |
| SCHEMBL3633138 | 0.85 | KDM4A (0.54) | KDM4ADYRK1AL3MBTL1 | |
| SCHEMBL23705506 | 0.83 | KDM4A (0.42) | GAAKDM4ASTK17BSTK17AMAPKAPK2 | |
| SCHEMBL29673310 | 0.83 | KDM4A (0.42) | GAAKDM4ASTK17BSTK17AMAPKAPK2 | |
| SCHEMBL29673308 | 0.83 | KDM4A (0.42) | GAAKDM4ASTK17BSTK17AMAPKAPK2 | |
| SCHEMBL22828360 | 0.82 | TRPA1 (0.50) | GAAKDM4AIDO1STK17BSTK17A | |
| SCHEMBL30097039 | 0.81 | NAMPT (0.45) | KDM4ASTK17BSTK17ADYRK1AL3MBTL1 | |
| SCHEMBL26143921 | 0.81 | NAMPT (0.45) | KDM4ASTK17BSTK17ADYRK1AL3MBTL1 | |
| SCHEMBL10547182 | 0.81 | ATR (0.46) | GAAKDM4AIDO1STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |