Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15884092 | 0.88 | CYP24A1 (0.36) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL2451086 | 0.85 | CYP24A1 (0.38) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL10663537 | 0.82 | CYP24A1 (0.37) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL1490570 | 0.79 | CYP24A1 (0.38) | CYP24A1TBXAS1AHRALDH1A1LMNA | |
| SCHEMBL21813970 | 0.78 | TBXAS1 (0.40) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL20565284 | 0.78 | CYP24A1 (0.37) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL26596806 | 0.78 | CYP24A1 (0.35) | CYP24A1TBXAS1 | |
| SCHEMBL22309159 | 0.78 | CYP24A1 (0.35) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL21813971 | 0.78 | TBXAS1 (0.40) | CYP24A1TBXAS1AHRFAAHMGLL | |
| SCHEMBL14158628 | 0.78 | CYP24A1 (0.37) | CYP24A1TBXAS1AHRFAAHMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12448400-B2 | KRAS G12D modulating compounds | GILEAD SCIENCES, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250136621-A1 | KRAS G12D MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2025-05-01 | — | — | US | disclosed |
| US-20250109147-A1 | KRAS G12D MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2025-04-03 | — | — | US | disclosed |
| WO-2025054530-A1 | PYRIMIDINE-CONTAINING POLYCYCLIC DERIVATIVES AS KRAS G12D MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2025-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12448400-B2 | KRAS G12D modulating compounds | KRAS, NRAS, HRAS | CYP24A1 3243/4885TBXAS1 3807/4885AHR 2238/4885 |
| US-20250136621-A1 | KRAS G12D MODULATING COMPOUNDS | KRAS, NRAS, HRAS | CYP24A1 3243/4885TBXAS1 3807/4885AHR 2238/4885 |
| US-20250109147-A1 | KRAS G12D MODULATING COMPOUNDS | KRAS, NRAS, HRAS | CYP24A1 3243/4885TBXAS1 3807/4885AHR 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.