SCHEMBL31408607

SCHEMBL31408607

COc1cnc(-c2cc3[nH]c(CNC(=O)[C@H](C)O)cc3cc2Cl)cn1

nearest known ligand 0.41

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PTGES O14684 18/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ LOXL2 Q9Y4K0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31408295 1.00 PTGES (0.41) PTGESSMN1; SMN2LOXL2
SCHEMBL31408503 1.00 PTGES (0.41) PTGESSMN1; SMN2LOXL2
SCHEMBL31408318 0.93 PTGES (0.40) PTGESSMN1; SMN2
SCHEMBL31408285 0.93 PTGES (0.40) PTGESSMN1; SMN2
SCHEMBL31408495 0.92 PTGES (0.41) PTGESSMN1; SMN2
SCHEMBL31408588 0.92 PTGES (0.41) PTGESSMN1; SMN2
SCHEMBL31408418 0.92 PTGES (0.41) PTGESSMN1; SMN2
SCHEMBL31408451 0.91 PTGES (0.38) PTGESSMN1; SMN2LOXL2
SCHEMBL31408411 0.91 PTGES (0.38) PTGESSMN1; SMN2LOXL2
SCHEMBL31408573 0.91 PTGES (0.38) PTGESSMN1; SMN2LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025049604-A1 INHIBITORS OF SOLUTE CARRIER FAMILY 6A MEMBER 19 (SLC6A19) AND METHODS OF USE THEREOF MAZE THERAPEUTICS, INC. (US) 2025-03-06 — — WO disclosed
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