SCHEMBL3141157

SCHEMBL3141157

CCC(C)Nc1cc(C(=O)O)c(C(F)(F)F)cc1C(N)=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 3/20 0.37
AKR1C3 P42330 2/20 0.36
AKR1C2 P52895 2/20 0.36
HSP90AA1 P07900 2/20 0.35
HSP90AB1 P08238 2/20 0.35
ASPH Q12797 1/20 0.35
SORT1 Q99523 3/20 0.34
TAS2R14 Q9NYV8 2/20 0.34
POLB P06746 2/20 0.33
MAPK1 P28482 1/20 0.33
BCL2L1 Q07817 1/20 0.33
MCL1 Q07820 1/20 0.33
MAPK8 P45983 1/20 0.33
MAPK10 P53779 1/20 0.33
HIPK2 Q9H2X6 1/20 0.33
KDM4E B2RXH2 2/20 0.33
ALDH1A1 P00352 2/20 0.33
RAB9A P51151 1/20 0.33
RPS6KB1 P23443 1/20 0.32
AKT1 P31749 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2427452 1.00 HCAR3 (0.37) HCAR3AKR1C3AKR1C2HSP90AA1HSP90AB1
SCHEMBL2421470 0.90 POLB (0.39) HCAR3AKR1C3AKR1C2HSP90AA1HSP90AB1
SCHEMBL2423686 0.89 CFTR (0.40) HSP90AA1HSP90AB1MAPK8MAPK10KDM4E
SCHEMBL2423689 0.89 CFTR (0.40) HSP90AA1HSP90AB1MAPK8MAPK10KDM4E
SCHEMBL2427839 0.87 KDM4E (0.38) HSP90AA1HSP90AB1MAPK8MAPK10KDM4E
SCHEMBL2424139 0.81 HSP90AA1 (0.46) HCAR3HSP90AA1HSP90AB1POLBMAPK1
SCHEMBL29460660 0.81 HSP90AA1 (0.46) HCAR3HSP90AA1HSP90AB1POLBMAPK1
SCHEMBL2428783 0.81 HCAR3 (0.40) HCAR3HSP90AA1HSP90AB1POLBMAPK1
SCHEMBL2424142 0.81 HSP90AA1 (0.46) HCAR3HSP90AA1HSP90AB1POLBMAPK1
SCHEMBL2426568 0.81 HSP90AA1 (0.46) HCAR3HSP90AA1HSP90AB1POLBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101910168-B Tropane compounds EXELIXIS INC 2014-07-30 CN disclosed
CN-101910168-A Tropane compounds EXELIXIS INC 2010-12-08 CN disclosed
EP-2074120-B1 TROPANE COMPOUNDS EXELIXIS INC (US) 2010-03-03 EP disclosed
EP-2074120-A1 TROPANE COMPOUNDS Exelixis, Inc. (US) 2009-07-01 EP disclosed
WO-2009055077-A1 TROPANE COMPOUNDS EXELIXIS, INC. (US) 2009-04-30 WO disclosed