Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850358 | 0.82 | NTRK1 (0.55) | MAPTHPGDALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL10120031 | 0.78 | MAPT (0.54) | MAPTHPGDPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL18216839 | 0.77 | GRN (0.56) | SMN1; SMN2ALDH1A1L3MBTL1GAATSHR | |
| SCHEMBL314283 | 0.75 | SMN1; SMN2 (0.47) | MAPTHPGDSMN1; SMN2ALDH1A1CYP2C19 | |
| Piperazine SCHEMBL15579214 | 0.75 | NTRK1 (0.48) | MAPTALDH1A1L3MBTL1CYP2C19GAA | |
| SCHEMBL28634605 | 0.73 | POLB (0.50) | MAPTHPGDPOLBALDH1A1L3MBTL1 | |
| SCHEMBL30128951 | 0.72 | POLB (0.43) | MAPTHPGDPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL28634607 | 0.72 | POLB (0.49) | MAPTHPGDPOLBALDH1A1L3MBTL1 | |
| SCHEMBL28580354 | 0.71 | GAA (0.52) | MAPTALDH1A1L3MBTL1CYP2C19GAA | |
| SCHEMBL28594274 | 0.71 | NTRK1 (0.56) | MAPTHPGDALDH1A1L3MBTL1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093251-B2 | Nitrogen-containing heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-01-10 | — | — | US | disclosed |