Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24952962 | 0.89 | GCK (0.44) | GCKSMN1; SMN2ALDH1A1HPGDNPSR1 | |
| SCHEMBL24953737 | 0.89 | GCK (0.44) | GCKSMN1; SMN2ALDH1A1HPGDNPSR1 | |
| SCHEMBL24953827 | 0.80 | GCK (0.45) | GCKKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL24952913 | 0.80 | GCK (0.38) | GCKSMN1; SMN2ALDH1A1 | |
| SCHEMBL24953916 | 0.80 | PSEN1 (0.40) | GCK | |
| SCHEMBL24953701 | 0.78 | MMP2 (0.39) | GCKLMNA | |
| SCHEMBL24953890 | 0.78 | CCNE1 (0.46) | KMT2AMAPTMEN1SMN1; SMN2NPC1 | |
| SCHEMBL24954122 | 0.77 | GCK (0.38) | GCK | |
| SCHEMBL24954124 | 0.77 | GCK (0.37) | GCKKMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL24954560 | 0.77 | GCK (0.35) | GCKKMT2AMAPTMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025002360-A1 | MRGPRX2 ANTAGONIST, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 北京普祺医药科技股份有限公司 | 2025-01-02 | — | — | WO | disclosed |