Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.42 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | INSR | P06213 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399523 | 0.89 | PIK3CD (0.47) | IGF1REGFRKDRINSRCYP3A4 | |
| SCHEMBL397798 | 0.88 | EGFR (0.47) | IGF1REGFRKDRINSRCYP3A4 | |
| SCHEMBL5138247 | 0.85 | IGF1R (0.42) | IGF1REGFRKDRINSRCYP3A4 | |
| SCHEMBL398652 | 0.79 | PIK3CD (0.43) | IGF1REGFRKDRINSRPIK3CG | |
| SCHEMBL400175 | 0.78 | PIK3CD (0.51) | IGF1REGFRKDRINSRCYP3A4 | |
| SCHEMBL400678 | 0.77 | BTK (0.50) | IGF1REGFRKDRINSRPIK3CG | |
| SCHEMBL5143848 | 0.77 | IGF1R (0.52) | IGF1REGFRKDRINSRCYP3A4 | |
| SCHEMBL396767 | 0.77 | EGFR (0.58) | IGF1REGFRKDRINSRCYP3A4 | |
| SCHEMBL400677 | 0.76 | PIK3CD (0.47) | IGF1REGFRKDRCYP3A4PIK3CG | |
| SCHEMBL5179813 | 0.76 | PIK3CD (0.46) | IGF1REGFRKDRPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-2168968-A1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |