Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.58 |
| ▸ | IGF1R | P08069 | 8/20 | 0.58 |
| ▸ | INSR | P06213 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.53 |
| ▸ | PRKDC | P78527 | 7/20 | 0.53 |
| ▸ | SRC | P12931 | 9/20 | 0.48 |
| ▸ | ABL1 | P00519 | 6/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.48 |
| ▸ | HCK | P08631 | 5/20 | 0.48 |
| ▸ | MTOR | P42345 | 5/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400175 | 0.91 | PIK3CD (0.51) | EGFRKDRIGF1RINSRCYP3A4 | |
| SCHEMBL5143848 | 0.90 | IGF1R (0.52) | EGFRKDRIGF1RINSRCYP3A4 | |
| SCHEMBL401880 | 0.89 | PIK3CD (0.48) | EGFRKDRIGF1RINSRCYP3A4 | |
| SCHEMBL399523 | 0.88 | PIK3CD (0.47) | EGFRKDRIGF1RINSRCYP3A4 | |
| SCHEMBL400844 | 0.88 | IGF1R (0.47) | EGFRKDRIGF1RINSRCYP3A4 | |
| SCHEMBL396331 | 0.87 | BTK (0.54) | EGFRKDRIGF1RINSRPIK3CG | |
| SCHEMBL398654 | 0.86 | IGF1R (0.57) | EGFRKDRIGF1RCYP3A4PIK3CG | |
| SCHEMBL401355 | 0.85 | PIK3CD (0.56) | EGFRKDRPIK3CGPIK3CDPIK3CA | |
| SCHEMBL400556 | 0.85 | PIK3CD (0.70) | EGFRKDRPIK3CGPIK3CDPIK3CA | |
| SCHEMBL400545 | 0.83 | IGF1R (0.69) | EGFRKDRIGF1RINSRPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | claimed |
| US-8735405-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-05-27 | — | — | US | claimed |
| US-20120196847-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2012-08-02 | — | — | US | claimed |
| EP-2168968-A1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, Inc. (US) | 2010-03-31 | — | — | EP | claimed |
| US-20080299113-A1 | Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-12-04 | — | — | US | claimed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | claimed |
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-01-17 | — | — | US | claimed |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | ACERTA PHARMA B.V. (NL) | 2006-10-19 | — | — | US | claimed |
| EP-2168968-B1 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS LLC (US) | 2017-08-23 | — | — | EP | disclosed |
| US-8735405-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| US-8653268-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2014-02-18 | — | — | US | disclosed |
| US-8575164-B2 | Combination cancer therapy | OSI Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-20130190496-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | OSI Pharmaceuticals, LLC | 2013-07-25 | — | — | US | disclosed |
| US-8367826-B2 | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI Pharmaceuticals, LLC (US) | 2013-02-05 | — | — | US | disclosed |
| US-20080267957-A1 | Combination cancer therapy | OSI PHARMACEUTICALS, INC. | 2008-10-30 | — | — | US | disclosed |
| EP-1979002-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI Pharmaceuticals, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | OSI PHARMACEUTICALS, INC. | 2008-01-17 | — | — | US | disclosed |
| WO-2007075554-A2 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | ACERTA PHARMA B.V. (NL) | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190496-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | IGF1R, MAP2K7, BRCA1 | EGFR 155/4885KDR 1497/4885IGF1R 1/4885 |
| US-20080014200-A1 | Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | IGF1R, IGFBP6, CDK6 | EGFR 27/4885KDR 958/4885IGF1R 1/4885 |
| US-20080299113-A1 | Combined treatment with and composition of 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents | IGF1R, EGFR, ERBB2 | EGFR 2/4885KDR 221/4885IGF1R 1/4885 |
| US-20120196847-A1 | 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors | IGF1R, MAP2K7, BRCA1 | EGFR 155/4885KDR 1497/4885IGF1R 1/4885 |
| US-20080267957-A1 | Combination cancer therapy | IGF1R, IGFBP4, IGFBP1 | EGFR 11/4885KDR 583/4885IGF1R 1/4885 |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | IGF1R, MAP2K7, BRCA1 | EGFR 155/4885KDR 1497/4885IGF1R 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.