⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599310 | 1.00 | — | — | |
| SCHEMBL3143039 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL8047319 | 0.98 | ALOX15 (0.48) | — | |
| Hydrochloric Acid SCHEMBL8047323 | 0.98 | ALOX15 (0.48) | — | |
| SCHEMBL11463704 | 0.83 | — | — | |
| SCHEMBL11463705 | 0.83 | — | — | |
| SCHEMBL2184545 | 0.81 | NPSR1 (0.61) | — | |
| SCHEMBL12602888 | 0.81 | NPSR1 (0.61) | — | |
| SCHEMBL12560982 | 0.81 | — | — | |
| SCHEMBL2184541 | 0.81 | NPSR1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642360-B2 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2010-01-05 | — | — | US | disclosed |
| WO-2009146696-A1 | USE OF INDOLE-3-CARBOXYLIC ESTERS FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE | Universität Tübingen (DE) | 2009-12-10 | — | — | WO | disclosed |
| US-7582121-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | L'OREAL S.A. (FR) | 2009-09-01 | — | — | US | disclosed |
| US-7488355-B2 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| US-7488356-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| US-7485156-B2 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | L'OREAL S.A. (FR) | 2009-02-03 | — | — | US | disclosed |
| US-7449585-B2 | Indazol-3-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-11-11 | — | — | US | disclosed |
| US-7449585-B2 | Indazol-3-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (VR1) | MERCK SHARP & DOHME LTD. (GB) | 2008-11-11 | — | — | US | disclosed |
| US-20080071092-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. | 2008-03-20 | — | — | US | disclosed |
| US-7285137-B2 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL, S.A. (FR) | 2007-10-23 | — | — | US | disclosed |
| EP-1687293-B1 | INDAZOL-3-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) | MERCK SHARP & DOHME (GB) | 2007-09-26 | — | — | EP | disclosed |
| US-20070129374-A1 | Indazol-3-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) | MERCK SHARP & DOHME LTD. (GB) | 2007-06-07 | — | — | US | disclosed |
| US-20070129374-A1 | Indazol-3-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) | MERCK SHARP & DOHME LTD. (GB) | 2007-06-07 | — | — | US | disclosed |
| US-20070006398-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one heterocyclic direct dye | L'OREAL S.A. (FR) | 2007-01-11 | — | — | US | disclosed |
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2005-08-04 | — | — | US | disclosed |
| US-4188489-A | Process for the production of 3-substituted amino-5-pyrazolones | FUJI PHOTO FILM CO., LTD. (JP) | 1980-02-12 | — | — | US | disclosed |