Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 14/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900426 | 1.00 | F2 (0.47) | F2PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL30387387 | 0.85 | MASP2 (0.51) | F2MASP2 | |
| SCHEMBL28842133 | 0.85 | MASP2 (0.51) | F2MASP2 | |
| SCHEMBL23478424 | 0.85 | MASP2 (0.51) | F2MASP2 | |
| SCHEMBL16814047 | 0.84 | KDM4A (0.44) | KDM4A | |
| SCHEMBL18360305 | 0.83 | CACNA1H (0.42) | F2PRSS1PRSS2PRSS3KDM4A | |
| SCHEMBL18179499 | 0.82 | KDM4A (0.42) | KDM4A | |
| SCHEMBL17920388 | 0.82 | MAPKAPK2 (0.43) | KLKB1KDM4AMAPKAPK2 | |
| SCHEMBL17442649 | 0.81 | KLKB1 (0.57) | F2PRSS1PRSS2PRSS3KLKB1 | |
| SCHEMBL23279842 | 0.79 | F2 (0.53) | F2PRSS1PRSS2PRSS3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |