Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27343898 | 1.00 | HCRTR2 (0.41) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL29317969 | 0.87 | MAOA (0.40) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL8252987 | 0.87 | MAOA (0.40) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL22604486 | 0.87 | HCRTR2 (0.41) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL10163707 | 0.85 | HCRTR2 (0.40) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL27343894 | 0.85 | MEN1 (0.41) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL6798730 | 0.85 | MEN1 (0.41) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL29318799 | 0.85 | HCRTR2 (0.40) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL8253836 | 0.85 | HCRTR2 (0.42) | HCRTR2TDP1MAOAMAOBMEN1 | |
| SCHEMBL22604487 | 0.85 | MEN1 (0.42) | HCRTR2TDP1MAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |