Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10642099 | 0.99 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL14000466 | 0.87 | CYP11B1 (0.46) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL31181858 | 0.87 | CYP11B1 (0.46) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL8052945 | 0.84 | GAA (0.38) | HSP90AA1HSP90AB1IDO1P2RX7CYP3A4 | |
| SCHEMBL10794314 | 0.81 | CYP11B1 (0.44) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL10794979 | 0.79 | CYP11B1 (0.44) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL9641140 | 0.78 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL9120568 | 0.78 | CYP19A1 (0.42) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL10790711 | 0.76 | CYP11B1 (0.54) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 | |
| SCHEMBL6774868 | 0.76 | CYP11B1 (0.54) | HSP90AA1HSP90AB1CYP11B1CYP11B2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323929-A1 | Purified Detomidine, Process of Preparing and Methods of Use | CLEXIO BIOSCIENCES LTD (IL) | 2021-10-21 | — | — | US | claimed |
| WO-2021037755-A1 | DETOMIDINE HYDROCHLORIDE MONOHYDRATE | SACHSE ANDREAS (DE) | 2021-03-04 | — | — | WO | claimed |
| EP-3782989-A1 | DETOMIDINE HYDROCHLORIDE MONOHYDRATE | Sachse, Andreas (DE) | 2021-02-24 | — | — | EP | claimed |
| US-20230398098-A1 | TOPICAL DETOMIDINE FORMULATIONS | CLEXIO BIOSCIENCES LTD. (IL) | 2023-12-14 | — | — | US | disclosed |
| US-20210323929-A1 | Purified Detomidine, Process of Preparing and Methods of Use | CLEXIO BIOSCIENCES LTD (IL) | 2021-10-21 | — | — | US | disclosed |
| US-20210220336-A1 | TOPICAL DETOMIDINE FORMULATIONS | CLEXIO BIOSCIENCES LTD. (IL) | 2021-07-22 | — | — | US | disclosed |
| EP-3782989-A1 | DETOMIDINE HYDROCHLORIDE MONOHYDRATE | Sachse, Andreas (DE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2020016827-A4 | PURIFIED CRYSTALLINE DETOMIDINE HYDROCHLORIDE MONOHYDRATE, ANHYDRATE AND FREE BASE WITH LOW AMOUNTS OF ISO-DETOMIDINE AND OTHER IMPURITIES BY RECRYSTALLISATION IN WATER | CLEXIO BIOSCIENCES LTD. (IL) | 2020-03-19 | — | — | WO | disclosed |
| WO-2020016827-A1 | PURIFIED CRYSTALLINE DETOMIDINE HYDROCHLORIDE MONOHYDRATE, ANHYDRATE AND FREE BASE WITH LOW AMOUNTS OF ISO-DETOMIDINE AND OTHER IMPURITIES BY RECRYSTALLISATION IN WATER | CLEXIO BIOSCIENCES LTD. (IL) | 2020-01-23 | — | — | WO | disclosed |
| WO-2020016827-A1 | PURIFIED CRYSTALLINE DETOMIDINE HYDROCHLORIDE MONOHYDRATE, ANHYDRATE AND FREE BASE WITH LOW AMOUNTS OF ISO-DETOMIDINE AND OTHER IMPURITIES BY RECRYSTALLISATION IN WATER | CLEXIO BIOSCIENCES LTD. (IL) | 2020-01-23 | — | — | WO | disclosed |
| US-7728147-B2 | Detomidine hydrochloride crystallization method | ORION CORPORATION (FI) | 2010-06-01 | — | — | US | disclosed |
| US-7728147-B2 | Detomidine hydrochloride crystallization method | ORION CORPORATION (FI) | 2010-06-01 | — | — | US | disclosed |
| US-7728147-B2 | Detomidine hydrochloride crystallization method | ORION CORPORATION (FI) | 2010-06-01 | — | — | US | disclosed |
| US-20080287685-A1 | Detomidine Hydrochloride Crystallization Method | ORION CORPORATION (FI) | 2008-11-20 | — | — | US | disclosed |
| US-20080287685-A1 | Detomidine Hydrochloride Crystallization Method | ORION CORPORATION (FI) | 2008-11-20 | — | — | US | disclosed |
| US-20080287685-A1 | Detomidine Hydrochloride Crystallization Method | ORION CORPORATION (FI) | 2008-11-20 | — | — | US | disclosed |
| WO-2006108910-A1 | DETOMIDINE HYDROCHLORIDE CRYSTALLIZATION METHOD | ORION CORPORATION (FI) | 2006-10-19 | — | — | WO | disclosed |
| EP-0146228-B1 | SUBSTITUTED 2-MERCAPTO-IMIDAZOLES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1988-01-20 | — | — | EP | disclosed |
| US-4584383-A | Substituted 2-mercapto-imidazoles and their preparation | FARMOS YHTYMA-OY (FI) | 1986-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323929-A1 | Purified Detomidine, Process of Preparing and Methods of Use | QDPR, DCTD, NEFM | HSP90AA1 2055/4885HSP90AB1 2522/4885CYP11B1 1089/4885 |
| US-20230398098-A1 | TOPICAL DETOMIDINE FORMULATIONS | QDPR, DDT, DCTD | HSP90AA1 1933/4885HSP90AB1 2117/4885CYP11B1 1940/4885 |
| US-20210220336-A1 | TOPICAL DETOMIDINE FORMULATIONS | QDPR, DDT, DCTD | HSP90AA1 1933/4885HSP90AB1 2117/4885CYP11B1 1940/4885 |
| US-20080287685-A1 | Detomidine Hydrochloride Crystallization Method | DDT, QDPR, NEFM | HSP90AA1 296/4885HSP90AB1 413/4885CYP11B1 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.