Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287561 | 1.00 | USP30 (0.47) | USP30GABRA5KDM4EMAPTTHRB | |
| SCHEMBL409282 | 0.85 | LMNA (0.50) | USP30KDM4EMAPTTSHRPOLB | |
| SCHEMBL5280075 | 0.83 | USP30 (0.42) | USP30KDM4EMAPTPKMPOLB | |
| SCHEMBL31039822 | 0.81 | KDM4E (0.54) | USP30KDM4EMAPTPKMPOLB | |
| SCHEMBL3522095 | 0.81 | KDM4E (0.54) | USP30KDM4EMAPTPKMPOLB | |
| SCHEMBL5293345 | 0.80 | SMN1; SMN2 (0.63) | KDM4EMAPTTHRBTSHRSMN1; SMN2 | |
| SCHEMBL13363886 | 0.77 | MAPT (0.54) | KDM4EMAPTAXLPOLBSMN1; SMN2 | |
| SCHEMBL18124102 | 0.76 | USP30 (0.55) | USP30KDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL13363878 | 0.76 | CYP46A1 (0.49) | USP30KDM4EMAPTTHRBSMN1; SMN2 | |
| SCHEMBL18987134 | 0.75 | CYP1A2 (0.65) | USP30KDM4EMAPTTHRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025085347-A1 | IL4I1 INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2025-04-24 | — | — | WO | disclosed |