Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 6/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143610 | 0.79 | NPC1 (0.50) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL27638750 | 0.79 | NPC1 (0.50) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL1304053 | 0.77 | GAA (0.59) | NPC1GRM4MTORRAB9AGAA | |
| SCHEMBL15181516 | 0.76 | MTOR (0.56) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL18878403 | 0.76 | NPC1 (0.47) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL19249155 | 0.76 | NPC1 (0.50) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL2411161 | 0.76 | NPC1 (0.47) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL26054257 | 0.76 | NPC1 (0.47) | NPC1GRM4KEAP1NOTUMMTOR | |
| SCHEMBL4796959 | 0.74 | ALKBH2 (0.69) | NPC1KEAP1RAB9A | |
| SCHEMBL20729400 | 0.72 | NPC1 (0.44) | NPC1GRM4KEAP1NOTUMMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-1836211-B1 | MACROLIDES | PFIZER PROD INC (US) | 2010-03-03 | — | — | EP | disclosed |