Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 14/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31439851 | 0.80 | CNR2 (0.54) | P2RX7CNR2 | |
| SCHEMBL31440066 | 0.74 | NOTUM (0.48) | NOTUMP2RX7NPC1 | |
| SCHEMBL10563487 | 0.74 | KMT2A (0.44) | ALDH1A1NOTUMP2RX7MAPT | |
| SCHEMBL631143 | 0.72 | KMT2A (0.50) | ALDH1A1P2RX7CNR2 | |
| SCHEMBL766149 | 0.72 | KMT2A (0.50) | ALDH1A1P2RX7CNR2 | |
| SCHEMBL24434739 | 0.72 | KMT2A (0.50) | ALDH1A1P2RX7CNR2 | |
| SCHEMBL9108096 | 0.70 | NOTUM (0.50) | NOTUMP2RX7 | |
| SCHEMBL9108102 | 0.70 | NOTUM (0.50) | NOTUMP2RX7 | |
| SCHEMBL9032092 | 0.69 | TDP1 (0.52) | ALDH1A1P2RX7CNR2 | |
| SCHEMBL9341749 | 0.69 | KDM4E (0.41) | P2RX7NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747260-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025021666-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-30 | — | — | WO | disclosed |