Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31440006 | 0.83 | NOTUM (0.45) | NOTUMHDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL18013330 | 0.78 | HDAC1 (0.44) | NOTUMHDAC1HDAC8HDAC6P2RX7 | |
| SCHEMBL21314741 | 0.78 | HDAC1 (0.38) | NOTUMHDAC1HDAC8HDAC6P2RX7 | |
| SCHEMBL21314738 | 0.78 | HDAC1 (0.38) | NOTUMHDAC1HDAC8HDAC6P2RX7 | |
| SCHEMBL31165435 | 0.77 | CCR1 (0.44) | NOTUMHDAC1HDAC8HDAC6P2RX7 | |
| SCHEMBL31440100 | 0.74 | ALDH1A1 (0.47) | NOTUMP2RX7NPC1 | |
| SCHEMBL849270 | 0.72 | POLB (0.46) | HDAC1HDAC8HDAC6KMT2ATSHR | |
| SCHEMBL848922 | 0.72 | POLB (0.46) | HDAC1HDAC8HDAC6KMT2ATSHR | |
| SCHEMBL848921 | 0.72 | POLB (0.46) | HDAC1HDAC8HDAC6KMT2ATSHR | |
| SCHEMBL9893095 | 0.71 | NOTUM (0.50) | NOTUMHDAC1HDAC8HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747260-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025021666-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-30 | — | — | WO | disclosed |