SCHEMBL31444192

SCHEMBL31444192

CNc1cccc(O[Si](C)(C)C(C)(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 4/20 0.42
CA1 P00915 4/20 0.42
CA9 Q16790 4/20 0.42
APP P05067 1/20 0.42
MEN1 O00255 2/20 0.40
MAPT P10636 2/20 0.40
MAPK1 P28482 2/20 0.40
KMT2A Q03164 2/20 0.40
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
PDK1 Q15118 1/20 0.36
PDK2 Q15119 1/20 0.36
PDK3 Q15120 1/20 0.36
PDK4 Q16654 1/20 0.36
TSHR P16473 2/20 0.34
PREP P48147 2/20 0.34
HTT P42858 2/20 0.33
NPC1 O15118 1/20 0.33
LMNA P02545 1/20 0.33
STAT1 P42224 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7706827 0.83 CA1 (0.50) CA12CA1CA9MEN1MAPT
SCHEMBL9479203 0.82 MEN1 (0.46) CA12CA1CA9MEN1MAPT
SCHEMBL6156617 0.82 CA12 (0.39) CA12CA1CA9MEN1MAPT
SCHEMBL28659308 0.82 APP (0.46) APPMEN1MAPTMAPK1KMT2A
SCHEMBL7683016 0.80 PDK1 (0.47) MEN1MAPTMAPK1KMT2AHSP90AA1
SCHEMBL12488338 0.80 CA12 (0.40) CA12CA1CA9MAPTHSP90AA1
SCHEMBL31738305 0.79 CA12 (0.37) CA12CA1CA9MEN1MAPT
SCHEMBL15995466 0.79 APP (0.46) CA12CA1CA9APPMEN1
SCHEMBL3182564 0.78 CA12 (0.46) CA12CA1CA9MEN1MAPT
SCHEMBL17362169 0.78 PREP (0.44) CA12CA1CA9APPMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096856-A1 COVALENT CEREBLON LIGANDS C4 THERAPEUTICS, INC. (US) 2025-05-08 WO disclosed