SCHEMBL31444710

SCHEMBL31444710

CN1C(=O)Cc2cc(Nc3nc(N4CCC(Nc5ccc6c(c5)nnn6C5CCC(=O)NC5=O)CC4)ncc3Cl)ccc21

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 14/20 0.39
▸ INSR P06213 5/20 0.36
▸ ALK Q9UM73 5/20 0.36
▸ NCOR2 Q9Y618 2/20 0.36
▸ MET P08581 1/20 0.36
▸ CRBN Q96SW2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31444637 0.87 BCL6 (0.43) BCL6NCOR2CRBN
SCHEMBL31520788 0.81 BCL6 (0.62) BCL6NCOR2
SCHEMBL31444600 0.81 BCL6 (0.37) BCL6INSRALKNCOR2CRBN
SCHEMBL30661491 0.81 DDB1 (0.54) BCL6INSRALKNCOR2CRBN
SCHEMBL26621606 0.81 DDB1 (0.54) BCL6INSRALKNCOR2CRBN
SCHEMBL26621480 0.81 DDB1 (0.54) BCL6INSRALKNCOR2CRBN
SCHEMBL30661506 0.81 DDB1 (0.54) BCL6INSRALKNCOR2CRBN
SCHEMBL26621594 0.81 DDB1 (0.54) BCL6INSRALKNCOR2CRBN
SCHEMBL31554707 0.80 BCL6 (0.61) BCL6NCOR2
SCHEMBL31444594 0.79 BCL6 (0.39) BCL6NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096710-A1 MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 — — WO disclosed
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