SCHEMBL31444600

SCHEMBL31444600

C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)CC(=O)N4C)n2)CC[C@H]1Nc1ccc2c(cnn2C2CCC(=O)NC2=O)c1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 16/20 0.37
▸ NCOR2 Q9Y618 4/20 0.37
▸ ROCK2 O75116 1/20 0.36
▸ DDB1 Q16531 1/20 0.36
▸ CRBN Q96SW2 1/20 0.36
▸ INSR P06213 2/20 0.36
▸ ALK Q9UM73 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31444662 0.92 CRBN (0.35) BCL6NCOR2DDB1CRBNINSR
SCHEMBL31444690 0.91 DDB1 (0.36) DDB1CRBNINSRALK
SCHEMBL31444594 0.90 BCL6 (0.39) BCL6NCOR2
SCHEMBL31444629 0.87 BCL6 (0.37) BCL6NCOR2ROCK2INSRALK
SCHEMBL31444549 0.85 INSR (0.39) BCL6NCOR2ROCK2INSRALK
SCHEMBL31702423 0.84 DDB1 (0.46) BCL6NCOR2DDB1CRBNINSR
SCHEMBL31702415 0.84 DDB1 (0.46) BCL6NCOR2DDB1CRBNINSR
SCHEMBL30661550 0.84 DDB1 (0.46) BCL6NCOR2DDB1CRBNINSR
SCHEMBL31702562 0.84 DDB1 (0.46) BCL6NCOR2DDB1CRBNINSR
SCHEMBL30661627 0.84 DDB1 (0.46) BCL6NCOR2DDB1CRBNINSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096710-A1 MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 — — WO disclosed
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