Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2864487 | 0.89 | SIRT2 (0.51) | SIRT2SIRT1MAPTNPC1RAB9A | |
| SCHEMBL13971438 | 0.84 | MAPT (0.56) | SIRT2SIRT1MAPTNPC1RAB9A | |
| SCHEMBL5839894 | 0.83 | MAPT (0.55) | SIRT2SIRT1MAPTNPC1RAB9A | |
| SCHEMBL13956740 | 0.82 | MAPT (0.73) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL4364678 | 0.81 | MAPT (0.52) | SIRT2SIRT1MAPTNPC1RAB9A | |
| SCHEMBL4363295 | 0.80 | MAPT (0.52) | SIRT2SIRT1MAPTNPC1RAB9A | |
| SCHEMBL13971233 | 0.79 | MAPT (0.74) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL13175624 | 0.78 | ALDH1A1 (0.54) | SIRT2SIRT1MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3718452 | 0.78 | SIRT2 (0.67) | SIRT2SIRT1MAPTTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3718449 | 0.78 | SIRT2 (0.67) | SIRT2SIRT1MAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747196-B1 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS INC (US) | 2010-02-10 | — | — | EP | claimed |