SCHEMBL31450719

SCHEMBL31450719

O=C(NS(=O)(=O)c1ccc(NCCCN2CCNCC2)c(S(=O)(=O)C(F)(F)F)c1)c1ccc(N2CCN(CC3=C(c4ccc(Cl)cc4)CC4(CCC4)CC3)CC2)cc1Oc1cnc2[nH]ccc2c1

nearest known ligand 0.77

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 17/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26648347 1.00 BCL2 (0.77) BCL2
SCHEMBL26648255 0.94 BCL2 (0.87) BCL2
SCHEMBL31450870 0.94 BCL2 (0.87) BCL2
SCHEMBL26648867 0.93 BCL2 (0.75) BCL2
SCHEMBL31450838 0.93 BCL2 (0.75) BCL2
SCHEMBL31450789 0.93 BCL2 (0.84) BCL2
SCHEMBL26648613 0.93 BCL2 (0.84) BCL2
SCHEMBL31450848 0.92 BCL2 (0.81) BCL2
SCHEMBL26648539 0.92 BCL2 (0.81) BCL2
SCHEMBL31450701 0.88 BCL2 (0.84) BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4522154-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-03-19 — — EP disclosed
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