Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 4/20 | 0.36 |
| ▸ | F13A1 | P00488 | 3/20 | 0.36 |
| ▸ | TGM1 | P22735 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31452085 | 0.85 | HTT (0.43) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL31452074 | 0.85 | MAPT (0.40) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL31452022 | 0.84 | HTT (0.41) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL28637939 | 0.82 | ALDH1A1 (0.47) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL30274613 | 0.82 | ALDH1A1 (0.47) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL20289588 | 0.82 | ALDH1A1 (0.47) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL24170423 | 0.82 | ALDH1A1 (0.46) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL20289582 | 0.82 | MAPT (0.46) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL24170057 | 0.81 | ALDH1A1 (0.46) | HTTALDH1A1MAPTNPC1MAPK1 | |
| SCHEMBL20289589 | 0.79 | ALDH1A1 (0.49) | HTTALDH1A1MAPTNPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250049809-A1 | INHIBITORS OF MUTANT IDH1 AND IDH2 | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2025-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250049809-A1 | INHIBITORS OF MUTANT IDH1 AND IDH2 | IDH1, IDH2, IDH3A | HTT 38/4885ALDH1A1 709/4885MAPT 2534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.