Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145492 | 1.00 | NOTUM (0.44) | NOTUMALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL7278393 | 0.70 | NOTUM (0.80) | NOTUMALDH1A1TSHRHTR2AHTR2C | |
| Acetic Acid SCHEMBL13279290 | 0.64 | HTR2A (0.55) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL21028083 | 0.63 | NOTUM (0.43) | NOTUMALDH1A1TSHRSIGMAR1 | |
| SCHEMBL9259627 | 0.63 | NOTUM (1.00) | NOTUMALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL30615209 | 0.63 | NOTUM (1.00) | NOTUMALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL8658423 | 0.60 | HTR2A (0.43) | NOTUMHTR2AHTR2CSIGMAR1 | |
| SCHEMBL28853394 | 0.59 | DAO (0.41) | NOTUMALDH1A1TSHRMAPTMCL1 | |
| SCHEMBL9658752 | 0.59 | NOTUM (0.57) | NOTUMALDH1A1TSHRHTR2AHTR2C | |
| SCHEMBL7379739 | 0.59 | NOTUM (0.62) | NOTUMALDH1A1TSHRHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449529-B1 | Protein Kinase C Inhibitors | LILLY CO ELI (US) | 2010-01-27 | — | — | EP | disclosed |