Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | ESR1 | P03372 | 4/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4763493 | 0.97 | TDP1 (0.80) | TDP1CYP3A4ESR1ESR2KDM4E | |
| SCHEMBL11170638 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL1776383 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL6387304 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL5167893 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL3156048 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL6392383 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL621886 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL6561245 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Bromide SCHEMBL417857 | 0.93 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483448-A | A kind of synthetic method of multichiral center gamma lactone class compound | UNIV WUYI | 2019-11-22 | — | — | CN | claimed |
| CN-119751392-A | Benzofuran compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 南方医科大学 | 2025-04-04 | — | — | CN | disclosed |
| EP-3805192-B1 | NOVEL BIPHENYL DERIVATIVE COMPOUND AND USE THEREOF | UNIV EWHA IND COLLABORATION (KR) | 2024-09-11 | — | — | EP | disclosed |
| CN-115385837-B | Method for preparing astaxanthin by oxidation of canthaxanthin | 万华化学集团股份有限公司 | 2024-04-09 | — | — | CN | disclosed |
| US-11939308-B2 | Biphenyl derivative compound and use thereof | EWHA University—Industry Collaboration Foundation (KR) | 2024-03-26 | — | — | US | disclosed |
| CN-113527388-B | Method for stereoselective synthesis of beta-2-deoxy sugar, 2-deoxy-2-azido sugar and glucosidic bond | 中国药科大学 | 2024-01-26 | — | — | CN | disclosed |
| CN-112512999-B | Novel biphenyl derivative compound and use thereof | 梨花女子大学产学协力团 | 2023-06-13 | — | — | CN | disclosed |
| CN-111747876-B | Method for preparing astaxanthin by oxidizing canthaxanthin | 万华化学集团股份有限公司 | 2023-05-26 | — | — | CN | disclosed |
| CN-116144192-A | Semi-cyanine near infrared two-region dye and preparation method and application thereof | 中山大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-115385837-A | Method for preparing astaxanthin through canthaxanthin oxidation | 万华化学集团股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-101842725-A | Optical element with optical adhesive layer and polarizer | SEIKO EPSON CORP | 2010-09-22 | — | — | CN | disclosed |
| US-20100081692-A1 | Novel 1-Benzyl-4-Piperidinamines that are Useful in the Treatment of COPD and Asthma | ASTRAZENECA AB (SE) | 2010-04-01 | — | — | US | disclosed |
| WO-2009020578-A1 | ALPHA2C ADRENORECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| CN-101351448-A | Novel 1-benzyl-4-piperidinamines for the treatment of COPD and asthma | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | CN | disclosed |
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| CN-1320599-A | Limited 9-cis-isotretinoins | AMERICAN CYANAMID CO (US) | 2001-11-07 | — | — | CN | disclosed |
| CN-1176248-A | Restricted 9-CIS-retinoids | AMERICAN CYANAMID CO (US) | 1998-03-18 | — | — | CN | disclosed |
| CN-1061594-A | Hydroxyalkyl quinoline ether acid as leukotriene antagonists | MERCK FROSST CANADA INT (CA) | 1992-06-03 | — | — | CN | disclosed |
| US-4605675-A | Polyene compounds useful in the treatment of allergic responses | USV PHARMACEUTICAL CORP. (US) | 1986-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11939308-B2 | Biphenyl derivative compound and use thereof | NDC1, NME1, NME4 | ACHE 3075/4885TDP1 2872/4885CYP3A4 3385/4885 |
| US-20100081692-A1 | Novel 1-Benzyl-4-Piperidinamines that are Useful in the Treatment of COPD and Asthma | CCR1, CCR4, CCR10 | ACHE 3964/4885TDP1 4153/4885CYP3A4 392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.