NME4

Nucleoside diphosphate kinase, mitochondrial · O00746 · NME4 on Sugi Atlas →

634 patent compounds predicted against NME4, 427 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Balsalazide (SCHEMBL118300)	1.00	3/20
Balsalazide (SCHEMBL138311)	1.00	3/20
Balsalazide (SCHEMBL3267109)	1.00	3/20
Balsalazide (SCHEMBL29377041)	1.00	3/20
Balsalazide (SCHEMBL134019)	0.97	3/20
Balsalazide (SCHEMBL5598491)	0.97	3/20
Balsalazide (SCHEMBL7908058)	0.97	3/20
Balsalazide (SCHEMBL28818120)	0.97	3/20
Balsalazide (SCHEMBL133200)	0.95	3/20
Balsalazide (SCHEMBL17392780)	0.87	3/20
Balsalazide (SCHEMBL20184744)	0.87	3/20
SCHEMBL2628412	0.80	3/20
SCHEMBL11160268	0.79	3/20
SCHEMBL14453551	0.76	3/20
SCHEMBL26843447	0.73	3/20
SCHEMBL2516217	0.71	3/20
SCHEMBL26850099	0.70	3/20
Balsalazide (SCHEMBL3667344)	0.68	3/20
Balsalazide (SCHEMBL30360)	0.67	3/20
SCHEMBL16778320	0.67	3/20

Clinical trials — most relevant to NME4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Use of New Drug QRX-3 for Prevention and Treatment of Chronic Kidney Disease Progression	PHASE2/PHASE3	NOT_YET_RECRUITING
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine	PHASE2	COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial	PHASE1/PHASE2	COMPLETED
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults	PHASE1	RECRUITING
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia	EARLY_PHASE1	ACTIVE_NOT_RECRUITING
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
Niacin Supplementation in Healthy Controls and Mitochondrial Myopathy Patients	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy	nan	RECRUITING
Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Metabolic Health in Individuals With Spinal Cord Injury (SCI)	nan	COMPLETED
Multi-omics Study in Citrin Deficiency	nan	ACTIVE_NOT_RECRUITING
NR Supplementation and Exercise	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence	nan	NOT_YET_RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Autologous Mitochondrial Transplant for Cerebral Ischemia	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a NME4 binder may also engage these)

Protein	Name	Similarity
P87355	—	0.993	P87355 →
Q9WV84	—	0.991	Q9WV84 →
O75414	—	0.979	O75414 →
O88426	—	0.977	O88426 →
Q86TL0	—	0.966	Q86TL0 →
MUS81	Structure-specific endonuclease subunit MUS81	0.966	landscape →
Q6DI51	—	0.966	Q6DI51 →
Q91ZJ0	—	0.966	Q91ZJ0 →
O88425	—	0.966	O88425 →
TARS2	Threonine--tRNA ligase, mitochondrial	0.965	landscape →
E2RDP2	—	0.965	E2RDP2 →
Q8VDP3	—	0.965	Q8VDP3 →
Q8BGV9	—	0.965	Q8BGV9 →
B3DL53	—	0.965	B3DL53 →
PTGES2	Prostaglandin E synthase 2	0.964	landscape →
Q8N8Q3	—	0.964	Q8N8Q3 →
Q6MG21	—	0.964	Q6MG21 →
P49753	—	0.964	P49753 →
Q8TDZ2	—	0.964	Q8TDZ2 →
P10937	—	0.963	P10937 →
Q5JTZ9	—	0.963	Q5JTZ9 →
P10938	—	0.963	P10938 →
Q9JJG9	—	0.963	Q9JJG9 →
Q9H3Z7	—	0.963	Q9H3Z7 →
D3ZX08	—	0.963	D3ZX08 →
Q68FW7	—	0.963	Q68FW7 →
Q9QYR9	—	0.962	Q9QYR9 →
TK2	Thymidine kinase 2, mitochondrial	0.962	landscape →
O55171	—	0.962	O55171 →
P51840	—	0.962	P51840 →