Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC1 | P19801 | 4/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21689084 | 0.84 | CYP17A1 (0.40) | AOC1AOC3CYP17A1TNFCYP2E1 | |
| SCHEMBL37676938 | 0.81 | TNF (0.40) | AOC1AOC3TNFCYP2E1CYP2C8 | |
| SCHEMBL3670639 | 0.81 | TNF (0.40) | AOC1AOC3TNFCYP2E1CYP2C8 | |
| SCHEMBL23674611 | 0.78 | CCNC (0.44) | AOC1AOC3TNFCYP2E1CYP2C8 | |
| SCHEMBL10526908 | 0.76 | HTT (0.42) | AOC1AOC3TNFCYP2E1CYP2C8 | |
| SCHEMBL360235 | 0.76 | TNF (0.37) | AOC1AOC3TNFCYP2E1CYP2C8 | |
| SCHEMBL31356313 | 0.76 | TNF (0.37) | AOC1AOC3TNFCYP2E1CYP2C8 | |
| SCHEMBL30915721 | 0.76 | GAA (0.42) | AOC1AOC3TNFCYP2A6LOXL2 | |
| SCHEMBL29215547 | 0.76 | GAA (0.42) | AOC1AOC3TNFCYP2A6LOXL2 | |
| SCHEMBL20519418 | 0.76 | GPBAR1 (0.36) | AOC1AOC3CYP17A1TNFCYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | GENENTECH, INC. (US) | 2025-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12208088-B2 | Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof | HIPK1, NEK1, HIPK2 | AOC1 1737/4885AOC3 2639/4885CYP17A1 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.